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目的：探讨临床应用马来酸桂哌齐特治疗急性脑梗死的神经保护作用及中长期预后。方法：90例急性脑梗死患者随机分为马来酸桂哌齐特治疗组(45例)和复方丹参对照组(45例)，比较治疗14d时神经功能评分(美国国立卫生研究院卒中量表评分，NIHSS及日常生活指数Barthel Index)以及血液炎症反应状态，随访90d比较两组患者改良Rankin评分评价中长期预后。结果：应用马来酸桂哌齐特治疗14d后，治疗组NIHSS评分较对照组显著下降，两组患者Barthel指数评分无统计学差异。同时，血液炎性细胞因子水平较对照组有显著下降。随访90d时治疗组改良Rankin评分明显优于对照组。结论：临床应用马来酸桂哌齐特治疗急性脑梗死有神经保护作用，降低炎性反应，改善中长期预后。“,”ABSTRACT:Aim: To investigate the therapeutic efficacy of cinepazide maleate on the acute cerebral infarction and the improvement of the prognosis of the disease. Methods: 90 patients with acute cerebral infarction were randomly divided into two groups, 45 cases treated with cinepazide maleate,45 cases treated with compound salvia miltiorrhiza injection. The scores of NIHSS and Barthel index and the serum inflammatory cytokines were estimated before and in 14 days after the treatment with cinepazide maleate. The score of Rankin scale was estimated in 90 days after the treatment. Results: Comparing to the control group, the score of NIHSS in treatment group was decreased significantly in 14 days after the treatment with cinepazide maleate. The scores of Barthel index were increased in both groups with no significant difference. Meanwhile, the blood inflammatory cytokines were significantly decreased in treatment group. In 90 days after the treatment, the Rankin score indicated that the treatment with cinepazide maleate could greatly improve the prognosis of the disease. Conclusion: The clinical application of cinepazide maleate on the acute cerebral infarction could protect the neurological function, lessen the inflammatory reaction, and improve the prognosis of the disease.