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目的:探讨肝病退黄汤直肠滴入治疗慢性乙型病毒性肝炎高胆红素血症的临床疗效。方法:50例慢性乙型病毒性肝炎高胆红素血症中医属湿热发黄证患者随机分为两组,对照组25例,治疗组25例。对照组患者给予常规内科综合治疗;治疗组在内科综合治疗基础上给予肝病退黄汤150ml直肠滴入,每日两次,疗程4周。治疗前及治疗4周后比较两组患者的临床转归、血清总胆红素、血清白蛋白、血清前白蛋白、总胆汁酸、凝血酶原活动度、乙肝DNA水平变化。结果:治疗组总有效率为88%,与对照组总有效率80%比较,差异无统计学意义;治疗组有效患者中患者的TBIL、TBA较对照组明显降低,ALB、PA、PTa明显升高;2组患者血清HBV-DNA水平均明显下降,差异无统计学意义。结论:对于慢性乙型病毒性肝炎属湿热发黄患者,在常规内科综合治疗的基础上,给予肝病退黄汤直肠滴入能够明显降低患者胆红素水平,改善肝功能,提高临床疗效。
Objective: To investigate the clinical effect of rehmanniae Decoction for treating chronic hepatitis B with hyperbilirubinemia. Methods: Fifty patients with chronic hepatitis B with hyperbilirubinemia were randomly divided into two groups: control group (25 cases) and treatment group (25 cases). Patients in the control group were given general internal medicine treatment. The treatment group was treated with rehmanniae dementia 150ml intrarectally and twice daily for 4 weeks on the basis of internal medicine comprehensive treatment. The clinical outcomes, serum total bilirubin, serum albumin, prealbumin, total bile acid, prothrombin activity, and HBV DNA levels in both groups were compared before treatment and after 4 weeks of treatment. Results: The total effective rate was 88% in the treatment group and 80% in the control group. There was no significant difference between the two groups. The TBIL and TBA in the effective group were significantly lower than those in the control group, ALB, PA and PTa were significantly increased High; serum HBV-DNA levels in two groups were significantly decreased, the difference was not statistically significant. Conclusion: For patients with chronic hepatitis B with damp heat and yellow fever, on the basis of general internal medicine treatment, rectal drip of liver detoxification can significantly reduce the level of bilirubin, improve liver function and improve clinical efficacy.