用香豆素衍生物作抗凝治疗可併发皮肤和软组织笻U庵植±砀谋涠捞氐乩奂霸谥瘟频降?～10天的女性患者,并倾向于发生在富有脂肪的乳腺、腹部、臀部和大腿等部位。自从1943年Flood首先报告此併发症以来,至今已报导了150例,大多数由双香豆素和双羟香豆素引起的。在1969年,美国广泛应用香豆素和华弗灵钠时,有4例发生皮肤坏死。作者报告治疗3例这种病人的经验。一例是54岁女性病 With coumarin derivatives for anticoagulant therapy can be complicated by skin and soft tissue 筇  U 植 plant 砀 涠 涠 涠 fishing 氐 乩 霸 霸 霸 霸 霸 Huan blast eradication frequency drop ~ 10 days of female patients and tend to occur in fatty Breast, abdomen, buttocks and thighs and other parts. Since the 1943 Flood first reported this complication, up to now 150 cases have been reported, most of which are caused by dicoumarol and dicoumarin. In 1969, 4 cases of skin necrosis occurred when coumarin and warfarin sodium were widely used in the United States. The authors report on the experience of treating 3 of these patients. An example is a 54-year-old female patient