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目的 :比较五种常用药物组合对慢性房颤患者静息及活动状态下心室率的控制作用。方法 :顺序住院的 6 0例慢性心房纤颤患者由不参与研究者随机分为五组 ,即A组 :单用地高辛 0 2 5mg d ;B组 :单用倍它乐克 5 0mg d ;C组 :单用异搏定 (缓释制剂 ) 2 40mg d ;D组 :0 2 5mg地高辛与 5 0mg倍它乐克联用 ;E组 :0 2 5mg地高辛与 2 40mg异搏定 (缓释制剂 )联用。每组 12例。统计处理用ANOVA、非参数统计、χ2 检验及配对t检验等方法。结果 :地高辛与倍它乐克联用组的心室率明显低于地高辛单用组 (P =0 0 0 0 )、单用倍它乐克组 (P =0 0 0 2 )和单用异搏定组(P =0 0 0 2 ) ;运动中 ,A组及D组治疗方案分别导致最高和最低的心室率反映 (114 33± 11 46与 10 0 83± 6 49次 min ,P =0 0 2 4) ;D组达到目标心室率所需时间最短 (2 33± 0 49)d ,而A组最长 (7 0 8± 1 93)d ;D组平均住院日短于其他各组 ,但只与A、B两组的差异有统计学意义 ;各治疗组患者心功能获得明显改善 ,但相关无统计学意义。结论 :地高辛单独使用控制心率效果最差 ,倍它乐克和缓释异搏定的疗效相当 ;地高辛与倍它乐克联用是最为理想的心率控制方案
OBJECTIVE: To compare the control effect of five commonly used drugs on ventricular rate at resting and active state in patients with chronic atrial fibrillation. Methods: Sixty consecutive patients with chronic atrial fibrillation admitted to hospital were randomly divided into five groups: group A: 0.252 mg of digoxin alone; group B: 50 mg of betamethasone alone; Group C: Vasopressin alone (sustained-release preparation) 2 40mg d; Group D: 025mg digoxin with 50mg bexarotene; Group E: 025mg digoxin and 240mg beriberi Set (slow release formulations) combined. 12 cases in each group. Statistical analysis using ANOVA, nonparametric statistics, χ2 test and paired t test and other methods. Results: Compared with digoxin alone group (P = 0 0 0), the ventricular rate was significantly lower in combination group of digoxin and betaxole (P = 0.00002) and In the exercise alone, the treatment regimens for groups A and D, respectively, resulted in the highest and lowest ventricular rate responses (114 33 ± 11 46 and 10 0 83 ± 6 49 min, respectively) P = 0 0 2 4). The shortest time required to reach the target ventricular rate in group D was (23.3 ± 0.49) d, the longest in group A was (70.8 ± 1.93) d. The average length of stay in group D was shorter than the others The differences between the two groups were statistically significant, but the differences between the two groups were statistically significant. The cardiac function in all treatment groups was significantly improved, but the correlation was not statistically significant. CONCLUSION: Digoxin alone has the worst effect on heart rate control. The efficacy of Betaloc and sustained-release verapamil is comparable. The combination of digoxin and Betaloc is the most ideal heart rate control