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目的:针对早期糖尿病肾病患者,讨论临床实施联合检测血清胱抑素C、β_2微球蛋白和尿微量白蛋白的临床价值,为日后的临床诊断提供参考与指导。方法:选择2013年2月至2015年3月,该院收治的早期糖尿病肾病患者120例为观察组,选择同期于我院进行健康体检的无疾病人员115例为对照组。两组人员,均于临床实施联合检测血清胱抑素C、β_2微球蛋白和尿微量白蛋白,对比两组人员的具体指标。结果:经过临床检测与数据搜集后,观察组患者的血清胱抑素C、β_2微球蛋白和尿微量白蛋白分别为(2.01±0.93)mg/L,(3.40±2.33)mg/L,(38.07±21.61)mg/L;对照组患者的血清胱抑素C、β_2微球蛋白和尿微量白蛋白分别为(0.97±0.69)mg/L,(1.43±0.72)mg/L,(14.05±3.49)mg/L,两组比较差异显著,具有统计学意义(P<0.05)。结论:通过对早期糖尿病肾病患者,于临床实施联合检测血清胱抑素C、β_2微球蛋白和尿微量白蛋白,可进一步提高诊断的准确性,搜集更多的资料与数据,为后续的治疗及护理提供参考,对患者的积极意义较大。建议在今后的临床诊断中,推广应用联合检测。
Objective: To discuss the clinical value of combined detection of serum cystatin C, β - microglobulin and urinary microalbuminuria in patients with early diabetic nephropathy and to provide reference and guidance for future clinical diagnosis. Methods: From February 2013 to March 2015, 120 patients with early diabetic nephropathy admitted to our hospital were selected as the observation group. 115 patients without disease in our hospital during the same period were selected as the control group. Two groups of patients, both in the clinical implementation of a joint detection of serum cystatin C, β 2 microglobulin and urine microalbumin, compared the two groups of specific indicators. Results: The serum cystatin C, β 2 microglobulin and urinary albumin in the observation group were (2.01 ± 0.93) mg / L and (3.40 ± 2.33) mg / L respectively after clinical examination and data collection, ( 38.07 ± 21.61) mg / L respectively. The levels of serum cystatin C, β 2 microglobulin and urine microalbumin in the control group were (0.97 ± 0.69) mg / L and (1.43 ± 0.72) mg / L, 3.49) mg / L, the difference between the two groups was significant, with statistical significance (P <0.05). Conclusions: Through the clinical implementation of combined detection of serum cystatin C, β-microglobulin and urinary microalbuminuria in patients with early diabetic nephropathy, the accuracy of diagnosis can be further improved and more data and data collected for subsequent treatment And care to provide a reference, the positive significance of patients larger. Recommended in the future clinical diagnosis, promote the use of joint testing.