比较了rioprostil夜间单剂600μg和300μg(一天2次)给药的抗分泌能力和作用时间,以及睡时单剂给药治疗急性十二指肠溃疡的效果。9名健康男性受试者,在三个不相连的间期(每期24小时)进行双盲交叉研究,各期于两个相同时间(晚11时半+晨8时半)接受的治疗依次为:安慰剂+安慰剂、本品300μg+300μ和本品600μg+安慰剂。每小时分析胃酸(H~+)活性1次。结果表明,本 Antisecretory ability and duration of action of rioprostil at 600 μg and 300 μg (twice a day) in the evening were compared with those of single-dose administration on acute duodenal ulcer at sleep. Nine healthy male subjects underwent double-blind crossover study in three non-consecutive periods (24 hours per period), and the treatments received in two phases at the same time (11.30 pm + 8.30 am) For: placebo + placebo, the product 300μg + 300μ and the product 600μg + placebo. Analyze gastric acid (H ~ +) activity once per hour. The results show that this