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目的探讨腺苷对病态窦房结综合征(SSS)和阵发性室上性心动过速的影响。方法17例SSS(1组),19例阵发性室上性心动过速(2组)和46例健康受试者(3组)。用大剂量腺苷及食管调搏术测定窦房结恢复时间(SNRT)、矫正后的窦房结恢复时间(CSNRT)及ADO:CSNRT(腺苷激发后的CSNRT)。结果SNRT长于2200ms和CSNRT长于550ms判定窦房结功能异常。食管调搏法CSNRT1组(3173.80±3377.07)ms,2组(342.59±264.54)ms,3组(282.45±83.24)ms;SNRT1组(4372.80±3159.58)ms,2组(1039.41±322.45)ms,3组(1016.45±85.22)ms;ADO1组(1921.25±1713.65)ms,2组未影响,3组未影响,组间差异有统计学意义(P<0.001)。结论腺苷对SSS的诊断有意义,而对阵发性室上性心动过速无影响。
Objective To investigate the effect of adenosine on sick sinus syndrome (SSS) and paroxysmal supraventricular tachycardia. Methods Seventeen SSS (group 1), 19 patients with paroxysmal supraventricular tachycardia (group 2) and 46 healthy subjects (group 3). The recovery time (SNRT), corrected sinus node recovery time (CSNRT) and ADO: CSNRT (adenosine challenged CSNRT) were measured with high dose adenosine and esophageal pacing. Results SNRT longer than 2200ms and CSNRT longer than 550ms to determine sinus node dysfunction. In esophageal pacing group, CSNRT1 group (3173.80 ± 3377.07) ms, group 2 (342.59 ± 264.54) ms, group 3 (282.45 ± 83.24) ms, group SNRT1 (4372.80 ± 3159.58) ms and group 2 (1039.41 ± 322.45) Group (1016.45 ± 85.22) ms; ADO1 group (1921.25 ± 1713.65) ms, two groups did not affect, three groups did not affect, the difference between groups was statistically significant (P <0.001). Conclusions Adenosine is of significance for the diagnosis of SSS and has no effect on paroxysmal supraventricular tachycardia.