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目的探讨非小细胞肺癌(NSCLC)骨转移的的特点及18F-脱氧葡萄糖正电子发射计算机断层摄影术(18F-FDG PET-CT)对NSCLC骨转移的诊断价值。资料与方法回顾性分析114例经病理证实的NSCLC患者的临床资料和18F-FDG PET-CT显像结果,并与CT结果进行对比。结果 NSCLC骨转移率为25.44%(29/114),其中腺癌36.21%(21/58),鳞癌14.89%(7/47),混合癌14.29%(1/7),2例大细胞肺癌患者未发生骨转移;共有骨转移病灶103处,骨转移好发部位为肋骨(34.95%)和胸椎(33.98%),其次是骨盆(13.59%)和腰椎(13.59%)。18 F-FDG PET-CT显像发现101处病灶,均呈放射性摄取增高,对NSCLC骨转移诊断的敏感性为98.06%;CT发现91处病灶,对NSCLC骨转移诊断的敏感性为88.35%;两者差别有统计学意义。结论 NSCLC中腺癌骨转移率最高,骨转移常见部位是肋骨和胸椎。18F-FDG PET-CT能发现CT所不能发现的早期NSCLC骨转移病灶,对NSCLC骨转移的正确诊断很有意义。
Objective To investigate the characteristics of bone metastasis in non-small cell lung cancer (NSCLC) and the diagnostic value of 18F-FDG PET-CT for bone metastasis of NSCLC. Materials and Methods Retrospective analysis of 114 cases of pathologically confirmed NSCLC patients with clinical data and 18F-FDG PET-CT imaging results and CT results were compared. Results The bone metastasis rate of NSCLC was 25.44% (29/114), including 36.21% (21/58) in adenocarcinoma, 14.89% (7/47) in squamous cell carcinoma, 14.29% (1/7) in mixed carcinoma and 2 cases of large cell lung cancer No bone metastasis occurred in 103 patients. There were 103 cases of bone metastases with ribs (34.95%) and thoracic vertebrae (33.98%), followed by pelvis (13.59%) and lumbar vertebrae (13.59%). In 18F-FDG PET-CT, 101 lesions were found to have increased radioactivity, and the sensitivity to diagnosing NSCLC bone metastasis was 98.06%. 91 lesions were detected by CT, and the sensitivity was 88.35% for the diagnosis of NSCLC bone metastasis. The difference between the two was statistically significant. Conclusions The highest rate of bone metastasis in adenocarcinoma is found in NSCLC. The common sites of bone metastasis are rib and thoracic vertebra. 18F-FDG PET-CT can detect early NSCLC bone metastases that CT can not detect, which is of great significance for the correct diagnosis of NSCLC bone metastases.