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为探讨非胰岛素依赖型糖尿病（ＮＩＤＤＭ）患者凝血及纤溶活性，采用ＥＬＩＳＡ双抗体夹心法测定了３５例ＮＩＤＤＭ患者的血浆Ｄ－二聚体。结果：ＮＩＤＤＭ患者血浆Ｄ－二聚体水平为１．６３ｍｇ／Ｌ±０．１４ｍｇ／Ｌ），明显高于正常对照组（０．３３ｍｇ／Ｌ±０．０９ｍｇ／Ｌ）（Ｐ＜０．０５）；有血管病变组Ｄ－二聚体为２．６２ｍｇ／Ｌ±０．６８ｍｇ／Ｌ，高于无血管病变组（０．６９ｍｇ／Ｌ±０．６８ｍｇ／Ｌ），差异有显著性（Ｐ＜０．００１）；血浆Ｄ－二聚体与ＦＢＧ、ＴＣ、ＴＧ相关分析表明Ｄ－二聚体与ＦＢＧ、ＴＧ呈正相关（分别为ｒ＝０．５８，Ｐ＜０．００１；ｒ＝０．０３５，Ｐ＞０．２；ｎ＝１４），与ＴＣ呈负相关（ｒ＝－０．０４５，Ｐ＞０．２，ｎ＝１４）。８例ＮＩＤＤＭ患者治疗后血浆Ｄ－二聚体较治疗前显著降低，分别为１．１１±０．８１，３．６５±１．２２，Ｐ＜０．０５）。提示ＮＩＤＤＭ患者体内存在高凝和继发纤溶活性亢进，血浆Ｄ－二聚体是反映ＮＩＤＤＭ患者高凝和缺血性疾病的诊断、疗效观察的良好指标。
To investigate the coagulation and fibrinolytic activity in non-insulin dependent diabetes mellitus (NIDDM) patients, plasma D-dimer was measured in 35 patients with NIDDM by sandwich ELISA. Results: The level of plasma D-dimer in NIDDM patients was 1.63 mg / L ± 0.14 mg / L, which was significantly higher than that of the normal control group (0.33 mg / L ± 0.09 mg / L) (P <0.05 ), D-dimer was 2.62mg / L ± 0.68mg / L in vascular group, which was significantly higher than that in non-vascular group (0.69mg / L ± 0.68mg / L) <0.001). Correlation analysis of plasma D-dimer with FBG, TC and TG showed that there was a positive correlation between D-dimer and FBG and TG (r = 0.58, P <0.001; r = 0 .035, P> 0.2; n = 14), negatively correlated with TC (r = -0.045, P> 0.2, n = 14). Plasma D-dimer levels in 8 NIDDM patients were significantly lower than those before treatment (1.11 ± 0.81, 3.65 ± 1.22, respectively, P <0.05). Prompt NIDDM patients with hypercoagulability and secondary fibrinolytic activity hyperthyroidism, plasma D-dimer is a good indicator of the diagnosis of NIDDM patients with hypercoagulability and ischemic disease, the efficacy observed.