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目的:亚临床动脉粥样硬化可以预测心血管事件的发生。评价脂肪测量指标体质量指数、腰臀比和体脂量在既往无心血管疾病的人群中对亚临床动脉粥样硬化的预测作用。方法:调查于2005-03/2006-11在法国巴黎心血管疾病预防中心完成。纳入进行冠心病一级预防的649例调查对象,年龄22～79岁,既往无心血管疾病史,绝大多数为白种人。应用高分辨率超声测量亚临床动脉粥样硬化指标,包括颈动脉内膜中层厚度以及冠状动脉外斑块数。肥胖测量指标包括体质量指数、腰臀比及体脂量,体脂量通过生理电阻抗分析的方法测定。分析肥胖测量指标与亚临床动脉粥样硬化、高冠心病危险和轻度炎症的关系。结果:肥胖测量指标体质量指数、腰臀比及体脂量与亚临床动脉粥样硬化的发生、高冠心病危险和轻度炎症均呈正相关(P<0.01)。在与亚临床动脉粥样硬化的发生与高冠心病危险的相关性中,体脂量的关系最强;在与轻度炎症的相关性中,腰臀比的作用最强。结论:体脂量与亚临床动脉粥样硬化最为紧密,调查结果提示体脂量可以作为预测成人心血管事件的参考指标。
Aims: Subclinical atherosclerosis can predict the occurrence of cardiovascular events. To assess the predictive value of body fat mass index, waist-hip ratio and body fat mass in subclinical atherosclerosis in a population without previous cardiovascular disease. METHODS: The survey was performed at the Cardiovascular Disease Prevention Center in Paris, France from March 2005 to November 2006. Inclusion of primary prevention of coronary heart disease, 649 cases of subjects, aged 22 to 79 years old, no previous history of cardiovascular disease, the vast majority of white people. Clinical signs of subclinical atherosclerosis were measured using high-resolution ultrasound, including carotid intima-media thickness and the number of extracorporeal plaques. Obesity measures include body mass index, waist-hip ratio and body fat, body fat by physiological impedance analysis method. To analyze the relationship between obesity measurement and subclinical atherosclerosis, high risk of coronary heart disease and mild inflammation. Results: Body mass index, waist-hip ratio and body fat were positively correlated with subclinical atherosclerosis, high CHD risk and mild inflammation (P <0.01). Body fat mass is most strongly associated with subclinical atherosclerosis and high-risk coronary disease; waist-hip ratio is most strongly associated with mild inflammation. Conclusion: Body fat and subclinical atherosclerosis the most closely, the results suggest that body fat can be used as a reference to predict cardiovascular events in adults.