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目的通过超声心动图测定的心室Tei指数评价恶性淋巴瘤患者化疗后早期心功能变化的临床意义。方法采用PHILIPS HDI 5000,Acuson Sequoia 512彩色多普勒超声诊断仪,对49例恶性淋巴瘤患者化疗前(Ⅰ组),化疗后(Ⅱ组)及30例正常人(Ⅲ组)进行二尖瓣前叶EF斜率、二尖瓣血流舒张早期最大流速(EV)与舒张末期最大流速(AV)的比值E/A等左心室舒张功能指标,射血分数(EF)、短轴缩短率(FS)等收缩功能指标,以及左心室Tei指数的测定。结果恶性淋巴瘤患者化疗后Ⅱ组患者左心室Tei指数大于Ⅰ组及Ⅲ组(P<0.01)。Ⅰ组及Ⅲ组间Tei指数差异无显著意义(P>0.05)。EF斜率、E/A、EF%及FS%各组间比较,差异无显著意义(P>0.05)。结论Tei指数能较敏感地对恶性淋巴瘤患者化疗后心功能改变进行评价,具有临床应用价值。
Objective To evaluate the clinical significance of early cardiac function changes in patients with malignant lymphoma after chemotherapy by measuring the ventricular Tei index measured by echocardiography. Methods 49 patients with malignant lymphoma before chemotherapy (group Ⅰ), after chemotherapy (group Ⅱ) and 30 normal subjects (group Ⅲ) were treated with PHILIPS HDI 5000 and Acuson Sequoia 512 color Doppler sonography. (EF), short axis shortening (FS), left ventricular diastolic function (EF) and left ventricular diastolic function (EF) ) And other systolic function indicators, as well as the determination of left ventricular Tei index. Results The Tei index of left ventricle in patients with malignant lymphoma after chemotherapy was higher than that of patients in group Ⅰ and Ⅲ (P <0.01). There was no significant difference in Tei index between group Ⅰ and group Ⅲ (P> 0.05). There was no significant difference in EF slope, E / A, EF% and FS% between groups (P> 0.05). Conclusion Tei index can be more sensitive to patients with malignant lymphoma after chemotherapy to evaluate changes in cardiac function, with clinical value.