论文部分内容阅读
钩状胡椒(Piper aduncum L.)的叶是巴布亚-新几内亚和南美地区所用的传统药。在体外筛选中,生药的石油醚提取物显示出强的的灭螺、抗菌活性和弱的抗真菌作用。生药的石油醚提取物在反相柱上经真空液相色谱提纯,选择预纯化部分浓缩得到结晶(1),为4-甲氧基-3,5-双(3-甲基-2-丁烯基)苯甲酸。进一步硅胶层析得(2)和(3),分别为莳萝脑和4-羟基-3-(3-甲基-2-丁烯基)苯甲酸甲酯。RP-HPLC提纯分离到(4)和(5),分别为4-
The leaves of Piper aduncum L. are traditional medicines used in Papua New Guinea and South America. In the in vitro screening, crude petroleum ether extracts of crude drugs showed strong molluscicidal, antibacterial activity and weak antifungal effects. The crude petroleum ether extract of the crude drug was purified by vacuum liquid chromatography on a reversed-phase column, and the pre-purified part was selected to be concentrated to obtain crystals (1) as 4-methoxy-3,5-bis(3-methyl-2-butane). Alkenyl) benzoic acid. Further silica gel chromatography gave (2) and (3) as dillolone and methyl 4-hydroxy-3-(3-methyl-2-butenyl)benzoate, respectively. Purified by RP-HPLC to (4) and (5), respectively, 4-