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目的 探讨红细胞多胺 (RBCPA)对诊断原发性肝癌 (PHC)的临床价值。方法 采用高效液相色谱法定量测定 5 6例消化系疾病患者血液中RBCPA的精胺Spd和Spm水平。 结果 消化系恶性肿瘤的Spd和Spm均极显著高于良性消化系疾病组 (P <0 0 1)。PHC组Spd非常显著高于良性消化系疾病组 (P <0 0 1)和非肝癌消化系恶性肿瘤组 (P <0 0 5 )。PHC组Spm与非肝癌消化系恶性肿瘤组间无差异 (P >0 0 5 )。PHC组敏感度 :Spd 90 % ,Spm 85 % ;特异度 :Spd 83 3% ,Spm 77 8%。 结论 红细胞多胺可作为肝癌的肿瘤标志物。联合检测AFP ,可提高诊断肝癌的敏感性和准确性 ,有互补作用。
Objective To investigate the clinical value of erythrocyte polyamine (RBCPA) in the diagnosis of primary hepatocellular carcinoma (PHC). Methods The levels of Spd and Spm in spermine of RBCPA in blood of 56 patients with digestive diseases were quantitatively determined by high performance liquid chromatography. Results Spd and Spm of digestive malignant tumors were significantly higher than that of benign digestive diseases (P <0.01). Spd in PHC group was significantly higher than that in benign digestive disease group (P <0.01) and non-HCC malignant tumor group (P <0.05). No difference was found between Spm of PHC group and malignant tumor of non-HCC digestive system (P> 0.05). Sensitivity of PHC group: Spd 90%, Spm 85%; Specificity: Spd 83 3%, Spm 77 8%. Conclusion Erythrocyte polyamine can be used as a tumor marker for liver cancer. Joint detection of AFP, can improve the sensitivity and accuracy of diagnosis of liver cancer, there are complementary effects.