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结缔组织生长因子(connective tissue growth factor,CTGF),是一种富含半胱氨酸的多肽[1],属于即刻早期基因家族(CCN)。由成纤维细胞、平滑肌细胞和内皮细胞合成分泌。成年哺乳动物心、脑、肾、肺、肝及胎盘组织中均有表达。在病理状态下,其过度表达与一些纤维增生性疾病的发生
Connective tissue growth factor (CTGF), a cysteine-rich polypeptide, belongs to the immediate early gene family (CCN). Secretion by fibroblasts, smooth muscle cells and endothelial cells. Adult mammalian heart, brain, kidney, lung, liver and placenta are expressed. Under pathological conditions, its overexpression and the occurrence of some fibroproliferative diseases