There is no conclusive answer to the question whether excising gall bladder is helpful to the patient with hepatic cancer.The survival rate of patients with hepatic cancer for more than two years has been increased,and the incidence of complications of cholecystitis and gall stone are relatively higher among these patients,which may seriously complicate treatment of advanced hepatic cancer and decrease quality of life.The researchers conducted a prospective clinical investigation from 2002 to 2006 to assess the clinical significance of preventive cholecystectomy in patients with hepatic cancer.One hundred and eighteen cases of postoperative patients with hepatic cancer,who survived for more than two years,were followed up.Based on whether cholecystectomy was performed,the patients were divided into two groups including 48 cases with cholecystectomy and 70 cases with cholecyst reserved.The two-year morbidity of gall stone and morbidity of pain in the right upper abdomen of cholecyst reservation group were 54.29% and 68.57%,respectively,obviously higher than 0.00% and 20.83% of cholecystectomy group.Mainly for those treated with transcatheter arterial chemo-embolization,the morbidity of gall stone was 86.67%(P＜0.01).Therefore,preventive cholecystectomy is strongly recommended during hepatectomy to decrease the incidence of chronic cholecystitis and gall stone,especially for those whose chemotherapy and embolization will be carried out through hepatic artery and portal vein.