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目的:监测综合性医院医院感染非发酵革兰阴性杆菌的分布和耐药状况。为临床用药和控制医院感染提供参考。方法:收集我院2006年7月1日至2009年6月30日548株非重复的医院感染非发酵革兰阴性杆菌,复核后采用琼脂稀释法进行体外敏感试验,按照美国临床和实验室标准协会(CLSI)2007年的标准测定MIC,以MIC50和MIC50表示抗菌药物的抗菌活性,并计算出耐药率(R%),中介率(I%)和敏感率(S%)。结果:14种抗菌药物对铜绿假单胞菌的抗菌活性敏感率从大到小依次为:美罗培南(81.5%),哌拉西林/三唑巴坦(77.8%),亚胺培南(73.6%),阿米卡星(72.7%)。鲍曼不动杆菌对亚胺培南,美罗培南,左氧沙星,头孢吡肟敏感性最高,敏感率分别为:78.5%,72.4%,69.5%,62.8%。结论:2种非发酵菌是一组多重耐药且耐药率较高的细菌,临床应根据药敏结果选用抗菌药物。
Objective: To monitor the distribution and drug resistance of non-fermentative gram-negative bacilli in nosocomial hospitals in general hospitals. For clinical medication and control of hospital infection provide a reference. Methods: A total of 548 noninfectious non-fermentative gram-negative bacilli were collected from our hospital from July 1, 2006 to June 30, 2009. Non-fermented Gram-negative bacilli were collected from our hospital from July 1, 2006 to June 30, 2009. The agar dilution method was used to conduct in vitro sensitivity test. According to the American Clinical and Laboratory Standards The MIC of CLSI was determined by CLSI in 2007, and the antibacterial activity of antibacterials was expressed by MIC50 and MIC50. The drug resistance rate (R%), mediation rate (I%) and sensitivity rate (S%) were also calculated. Results: The sensitivity rates of antimicrobial agents to Pseudomonas aeruginosa from 14 kinds of antibacterials were as follows: Meropenem (81.5%), Piperacillin / Tazobactam (77.8%), Imipenem (73.6 %), Amikacin (72.7%). Acinetobacter baumanii had the highest sensitivity to imipenem, meropenem, levofloxacin and cefepime, the sensitivity rates were 78.5%, 72.4%, 69.5% and 62.8%, respectively. Conclusion: The two kinds of non-fermentative bacteria are a group of multi-drug resistant and high resistant bacteria, clinical antimicrobial drugs should be selected based on drug susceptibility results.