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目的:比较醋酸曲普瑞林与醋酸亮丙瑞林缓释微球治疗特发性中枢性早熟的临床效果。方法:将特发性中枢性早熟女童74例随机分为A组与B组各37例。A组予醋酸曲普瑞林治疗,B组予醋酸亮丙瑞林缓释微球治疗。两组疗程均为6个月。比较两组治疗前后性激素水平、BA/CA、身高、体重指数、子宫体积、卵巢体积变化及药品不良反应发生情况。结果:两组治疗后血清FSH、E2、LH水平较前明显下降(P<0.05);且A组血清FSH、E2、LH水平显著低于B组(P<0.05),治疗前后血清FSH、E2、LH差值明显高于B组(P<0.05)。两组BA/CA和体重指数较前明显下降,身高较前明显增加(P<0.05);且A组BA/CA和体重指数显著低于B组,身高显著高于B组(P<0.05);A组治疗前后BA/CA、身高及体重指数差值均高于B组(P<0.05)。治疗后两组子宫体积和卵巢体积均较前明显降低(P<0.05),且A组子宫体积和卵巢体积显著低于B组(P<0.05),治疗前后子宫体积和卵巢体积差值高于B组(P<0.05)。两组药品不良反应发生率的差异无统计学意义(P>0.05)。结论:醋酸曲普瑞林用于特发性中枢性早熟患儿效果优于醋酸亮丙瑞林缓释微球,且无严重不良反应,用药安全性良好。
Objective: To compare the clinical efficacy of triptorelin acetate with leuprolide microspheres in the treatment of idiopathic central precocious puberty. Methods: 74 cases of idiopathic central precocious puberty girls were randomly divided into A group and B group of 37 cases. A group to triptorelin acetate treatment, B group leuprolide acetate sustained-release microspheres treatment. Two courses of treatment are 6 months. The levels of sex hormones, BA / CA, height, body mass index, uterine volume, ovarian volume changes and adverse drug reactions were compared between the two groups before and after treatment. Results: Serum levels of FSH, E2 and LH were significantly decreased in both groups after treatment (P <0.05). Serum levels of FSH, E2 and LH in group A were significantly lower than those in group B (P <0.05) , LH difference was significantly higher than the B group (P <0.05). The BA / CA and body mass index in two groups were significantly lower than those in the previous two groups (P <0.05). The BA / CA and body mass index in group A were significantly lower than those in group B (P <0.05) ; The difference of BA / CA before and after treatment in group A was higher than that in group B (P <0.05). After treatment, the uterine volume and the ovarian volume in both groups were significantly lower than before (P <0.05), and the volume of uterus and ovary in group A were significantly lower than those in group B (P <0.05). Before and after treatment, the difference between uterine volume and ovarian volume was higher Group B (P <0.05). There was no significant difference in the incidence of adverse drug reactions between the two groups (P> 0.05). CONCLUSION: Triptorelin acetate is superior to leuprolide acetate-releasing microspheres in children with idiopathic central precocious puberty and has no serious side effects. The medication is safe.