目的对比观察强化胰岛素治疗与口服药治疗2型糖尿病合并慢性阻塞性肺病的临床效果。方法选择2016年2月~2017年2月我院收录诊治的2型糖尿病合并慢性阻塞性肺病患者92例作为本次对比治疗的研究对象,将其无规则随机平分为两个治疗组,即强化组与口服组,各46例。短期内给予强化组强化胰岛素治疗方案,而对口服组则采取口服降糖药物治疗方案。两组2型糖尿病合并慢性阻塞性肺病患者均持续治疗2周后,对比观察及研究其血糖控制效果以及胰岛功能恢复情况。结果强化组患者经强化胰岛素治疗2周后,其血糖的总有效控制率为97.83%(45/46),而口服组的为82.61%(38/46),对比研究其统计学意义具有鲜明的差异性(P<0.05);检测所得强化组患者治疗后的空腹状态下的血糖和糖化血红蛋白值以及餐后2 h血糖值均明显降低,且显著低于口服组(P<0.05);并且强化组用药期间发生不良药物副反应率为2.17%(1/46),而口服组的为17.39%(8/46),对比检验(P<0.05)。另外,研究发现,治疗后的强化组患者的胰岛功能分泌指数显著较高于口服组,表明其胰岛功能恢复情况良好。结论强化胰岛素治疗相比于口服降糖药物治疗,更值得用于首诊2型糖尿病合并慢性阻塞性肺病患者,其于短期内即可产生非常显著的血糖控制效果,提高血糖控制总有效率,值得在临床实践治疗中给予官方推广。 Objective To compare the clinical effects of intensive insulin therapy and oral medication in the treatment of type 2 diabetes mellitus combined with chronic obstructive pulmonary disease. Methods From February 2016 to February 2017, 92 patients with type 2 diabetes mellitus complicated with chronic obstructive pulmonary disease (COPD) treated in our hospital were selected as the subjects of this comparative treatment and randomly divided into two treatment groups randomly Group and oral group, each 46 cases. In the short term, intensive treatment with intensive insulin was given, whereas in the oral group, oral hypoglycemic agents were used. Two groups of patients with type 2 diabetes mellitus and chronic obstructive pulmonary disease patients were treated for 2 weeks after the continuous observation and study of its blood glucose control effect and recovery of islet function. Results After 2 weeks of intensive insulin therapy, the total effective rate of blood glucose control in the intensive group was 97.83% (45/46) compared with 82.61% (38/46) in the oral group, and its statistical significance was clear (P <0.05). The fasting glucose and hemoglobin (HbA1c) values ​​and the 2h postprandial blood glucose values ​​in the intensive group were significantly lower than those in the oral group (P <0.05) The incidence of side effects of adverse drug reactions was 2.17% (1/46) during the course of treatment, compared with 17.39% (8/46) for the oral administration, compared with the control (P <0.05). In addition, the study found that, after treatment, the intensive group of patients with pancreatic function secretion index was significantly higher than the oral group, indicating that its pancreatic islet function recovered well. Conclusion Compared with oral hypoglycemic drugs, intensive insulin therapy is more suitable for the first diagnosis of type 2 diabetes mellitus patients with chronic obstructive pulmonary disease, which can produce very significant blood sugar control effect in a short period of time and improve the total effective rate of blood sugar control. It is worth in the clinical practice of treatment to give the official promotion.