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目的探讨体位变换和药物保留时间对膀胱癌术后患者的影响。方法选取收治的458例行膀胱癌部分切除术的患者,随机分为研究组和对照组,各229例。术后两周灌注吡喃阿霉素,两组体位变换以及药物保留时间不同,观察两组复发以及并发症发生情况。结果两组术后2年复发率对比差异具有统计学意义(P<0.05),研究组血尿、尿频尿痛、前列腺炎、尿道狭窄以及膀胱刺激症状发生率明显低于对照组,两组对比差异均具有统计学意义(P<0.05)。结论膀胱癌术后膀胱内灌注化疗药物及时变换体位,可使药物得到充分吸收。选择合理的保留药物时间,减少了膀胱和尿道的刺激,预防肿瘤复发,降低不良反应发生率。
Objective To investigate the effect of postural change and drug retention on postoperative patients with bladder cancer. Methods A total of 458 patients undergoing partial resection of bladder cancer were randomly divided into study group and control group, with 229 cases in each group. Perioperative perfusion of pirarubicin two weeks after surgery, two groups of position changes and drug retention time was different, the two groups were observed recurrence and complications. Results There was significant difference in recurrence rate between the two groups at 2 years (P <0.05). The incidences of hematuria, frequent urination and pain, prostatitis, urethral stricture and bladder irritation in the study group were significantly lower than those in the control group All were statistically significant (P <0.05). Conclusion Intravesical instillation of chemotherapeutic agents in bladder cancer can change position in time and the drug can be fully absorbed. Choose a reasonable retention time of the drug, reducing the bladder and urinary tract irritation, prevent tumor recurrence and reduce the incidence of adverse reactions.