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为了探讨非胰岛素依赖型糖尿病（ＮＩＤＤＭ）患者的血脂〔甘油三酯（ＴＧ）、胆固醇（ＴＣ）、高密度脂蛋白－胆固醇（ＨＤＬ－Ｃ）〕、载脂蛋白〔载脂蛋白ＡＩ（ＡｐｏＡＩ）、载脂蛋白Ｂ（ＡｐｏＢ）〕、脂蛋白（ａ）〔Ｌｐ（ａ）〕的水平及临床意义，观察了１２７例正常人、９２例无并发症和２２例并发肾功能损害的ＮＩＤＤＭ患者三者变化情况，发现ＮＩＤＤＭ患者Ｌｐ（ａ）、ＴＧ、ＡｐｏＡＩ与对照组相比有显著差异（Ｐ＜０．０５）；伴肾功能损害者Ｌｐ（ａ）水平比无肾功损害者明显升高（Ｐ＜０．０５）。说明ＮＩＤＤＭ患者血脂代谢异常、Ｌｐ（ａ）水平升高可能对其肾功能损害起一定作用。
To investigate the effects of apolipoprotein A (apolipoprotein AI) on serum lipids (TG, TC, HDL-C) in patients with non-insulin dependent diabetes mellitus (NIDDM) , ApoB], and lipoprotein (a) [Lp (a)] were measured in 127 normal subjects and 92 non-complication cases and 22 patients with NIDDM complicated with renal dysfunction The changes of Lp (a), TG and ApoAI in patients with NIDDM were significantly different from those in control group (P <0.05). The levels of Lp (a) in patients with renal dysfunction were significantly higher than those without renal damage (P <0.05). Description NIDDM patients with abnormal lipid metabolism, Lp (a) levels may play a role in their renal damage.