越来越多的证据证实醛固酮具有心脏毒性作用,它可导致心肌炎症、内皮细胞功能失调和纤维化,由于存在着醛固酮逃逸现象,醛固酮拮抗剂在充血性心力衰竭中的作用日益受到重视。选择性醛固酮拮抗剂依普利酮能有效地降低充血性心力衰竭病人的死亡率,而与性激素相关的不良反应远较传统醛固酮拮抗剂螺内酯小,有望成为心血管领域中的广泛用药。 There is growing evidence that aldosterone has cardiotoxic effects, which can lead to myocardial inflammation, endothelial cell dysfunction and fibrosis. The role of aldosterone antagonists in congestive heart failure is gaining more and more attention because of aldosterone escaping. The selective aldosterone antagonist eplerenone can effectively reduce the mortality of patients with congestive heart failure, and sex hormone-related adverse reactions than traditional aldosterone antagonist spironolactone is small, is expected to become widely used in the cardiovascular field.