一系列研究工作证明了免避发病机理和凝血障碍与人类肾小球疾病(GD)有关,在多数GD中,免疫发病过程是引起病变的关键而凝血启动则是病变持续发展和肾功能进行性恶化的重要因素之一。显然,抗凝治疗对防治GD的发生和发展具有一定的重要意义。一本文主要讨论GD凝血障碍与抗凝治疗的若干问题。一、GD凝血系统激活的原理大量研究表明,GD的一系列病理改变,主要与补体激活以后随之产生的一系列反应有关,即肾内产生炎症反应和凝血启动的结果。各种因素:如免疫复合物(IC)、肾小球内皮细胞损伤,胶原物质(Ⅵ、Ⅴ型)、细菌内毒素,病毒感染,组织 A series of studies have demonstrated that the pathogenesis of avoidance and coagulopathy are associated with human glomerular disease (GD). In most GDs, the immunopathogenesis is the key to disease progression and coagulation is associated with sustained disease progression and progressive renal function One of the important factors of deterioration. Obviously, anticoagulant therapy is of great importance for prevention and treatment of the occurrence and development of GD. This article discusses several issues related to coagulopathy and anticoagulation in GD. First, the principle of activation of the GD coagulation system A large number of studies have shown that a series of pathological changes in GD, mainly associated with a series of reactions resulting after complement activation, that is, the result of renal inflammation and coagulation. Various factors: such as immune complex (IC), glomerular endothelial cell damage, collagen material (Ⅵ, Ⅴ), bacterial endotoxin, viral infection, tissue