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目的探讨新型光敏剂ATX-S10.Na(Ⅱ)在大鼠脑胶质瘤模型不同组织中的分布和代谢。方法在已经建立的SD大鼠C6胶质瘤模型中,经尾静脉注射ATX-S10.Na(Ⅱ)(20mg/kg)。分别于1h、2h、4h、8h、12h和24h后处死并取出大鼠的血液、皮肤、肿瘤组织、瘤周组织以及对侧正常脑组织,应用荧光分光光度计连续测定ATX-S10.Na(Ⅱ)在大鼠C6胶质瘤模型各种组织中的分布和代谢。结果ATX-S10.Na(Ⅱ)的药物浓度于静脉注射2h后在肿瘤组织中达到峰值,以后8h维持在一个持续较高的水平,显著高于对侧正常脑组织及瘤周组织。而正常皮肤和脑组织中也吸收少量的药物,但是它们峰值很低,并且几乎均在4h内完全代谢消失。结论新型光敏剂ATX-S10.Na(Ⅱ)具有优良的胶质瘤组织与正常脑组织的对比度,并且能快速从体内清除。
Objective To investigate the distribution and metabolism of a novel photosensitizer ATX-S10.Na (Ⅱ) in different tissues of rat glioma model. Methods ATX-S10.Na (Ⅱ) (20 mg / kg) was injected into tail vein through established rat C6 glioma model. The blood, skin, tumor, peritumoral tissues and the contralateral normal brain tissues of rats were sacrificed at 1h, 2h, 4h, 8h, 12h and 24h respectively. The fluorescence intensity of ATX-S10.Na Ⅱ) Distribution and Metabolism in Various Tissues of Rat C6 Glioma Model. Results The drug concentration of ATX-S10.Na (Ⅱ) peaked in tumor tissue at 2h after intravenous injection, and maintained at a sustained high level at 8h, which was significantly higher than that in normal contralateral normal brain and peritumoral tissues. While normal skin and brain tissue also absorb small amounts of drugs, they peak at very low levels and almost completely disappear within 4 h. Conclusion The new photosensitizer ATX-S10.Na (Ⅱ) has excellent glioma tissue and normal brain tissue contrast, and can quickly remove from the body.