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骨髓异常增生综合征(MDS)外周血中出现体积大、形态异常的血小板已有报道,但其特异性及临床意义还不清楚。本文作者用相差显微镜检查MDS病人的血小板时,识别出一种在其他病人或正常人中罕见的异常血小板亚群,并研究了它对MDS的诊断及临床的价值。 MDS病人27例(其中2例RA,6例RSA,13例RAEB,1例CMML,5例RAEB-t,均按FAB进行分类),大部分病人未经治疗,少数病人以前用过维甲酸。以69例不同血液病病人(其中48例恶性血液疾患,21例良性血液疾患)及9例正常人为对照。采手指尖血,迅速用Kristenson′s溶液稀释20倍,在相差显微镜下每份标本计数200个血小板,对血小板严重减少的病例,则计数其2-4周内几次检查的总和。将异常血小板>1%作为病理指标。异常血小
In the peripheral blood of patients with myelodysplastic syndrome (MDS), bulky and morphologically abnormal platelets have been reported, but its specificity and clinical significance are still unclear. When the authors examined platelets in MDS patients by phase-contrast microscopy, they identified a subset of abnormal platelets that were uncommon in other patients or normal subjects and studied their diagnostic and clinical value for MDS. A total of 27 patients with MDS (2 RA, 6 RSA, 13 RAEB, 1 CME, 5 RAEB-t, all classified according to FAB) were untreated and a minority of patients had previously used tretinoin. 69 patients with different blood diseases (48 cases of hematological malignancies, 21 cases of benign blood diseases) and 9 normal controls. Fingertip blood samples were taken, rapidly diluted 20 times with Kristenson’s solution, counted 200 platelets per specimen under a phase contrast microscope, and counted for a few 2-4 weeks for severely reduced platelets. Abnormal platelet> 1% as a pathological index. Abnormal blood