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为确定乳癌淋巴结阴性者在肿块切除后同侧乳房肿瘤复发(IBTR)是否为提示远处转移与死亡率的独立指征,作者对837例随机分组作了研究。全部病例原发肿瘤≤4cm,切缘净,组织学证实淋巴结(一)。A组416例接受放疗,全乳照射40Gy/16次,继之原发灶处局部增强12.5Gy/5次。B组421例作为对照(不放疗)。均未作全身化疗。用Kaplan-Meier法计算总生存,A组的生存曲线用Mantel-COX试验
To determine whether ipsilateral breast tumor recurrence (IBTR) after lumpectomy in breast cancer node-negative individuals is an independent indicator of distant metastasis and mortality, the authors studied 837 randomized subgroups. In all cases, the primary tumor was ≤4 cm, the margin was clean, and histologically confirmed lymph nodes (1). In Group A, 416 patients received radiotherapy, and 40Gy/16 times of whole breast irradiation, followed by local enhancement of 12.5Gy/5 times. 421 cases in group B served as controls (no radiotherapy). No systemic chemotherapy was performed. Overall survival was calculated using the Kaplan-Meier method. Mantle-COX test was used for the survival curve of group A.