论文部分内容阅读
因血吸虫重组疫苗是一种弱免疫原，佐剂在提呈这种弱免疫原上起着十分重要的作用。本实验结果显示日本血吸虫成虫粗抗原与佐剂ＦＣＡ、Ｆｅ（ＯＨ）＋３、Ｆｅ（ＯＨ）－３、鱼油及参环毛蚓分别免疫小鼠，所得减虫率分别为３３．３９％、４１．８９％、３５．４３％、４０．３％、４８．７５％。其中，Ｆｅ（ＯＨ）－３与ＦＣＡ、Ｆｅ（ＯＨ）＋３与鱼油之间无显著性差异（Ｐ＞０．０５），但后两者效果显著优于前两者（Ｐ＜０．０１），参环毛蚓的效果又显著优于Ｆｅ（ＯＨ）＋３和鱼油（Ｐ＜０．０１）。
Since the recombinant schistosome vaccine is a weak immunogen, adjuvants play a very important role in presenting such weak immunogens. The results of this experiment showed that the adult mice immunized with the crude antigen of Schistosoma japonicum and the adjuvants FCA, Fe (OH) + 3, Fe (OH) -3, fish oil and epiphyseal worms respectively, the worm reduction rates were 33.39%, 41 .89%, 35.43%, 40.3%, 48.75%. There was no significant difference between Fe (OH) -3 and FCA, Fe (OH) +3 and fish oil (P> 0.05), but the latter two effects were significantly better than the former two (P <0.01) , The effect of earthworm was significantly better than that of Fe (OH) +3 and fish oil (P <0.01).