制备了含重组溶葡萄球菌酶和溶菌酶的水胶体创口敷料,并考察其在体外不同时间点的酶活性,以及细菌杀灭率、重量差异、微生物限度。结果表明,所得制品体外释放完全,对大肠杆菌、金黄色葡萄球菌、铜绿假单胞菌和白色念珠菌的杀菌率均在90%以上,重量差异在±7.5%以内,且微生物限度检验结果符合要求。 Hydrocolloid wound dressings containing recombinant lysostaphin and lysozyme were prepared and investigated for enzyme activity at different time points in vitro as well as bacterial kill rates, weight differences, and microbial limits. The results showed that the obtained products were completely released in vitro and the bactericidal rates against E. coli, Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans were above 90% and the weight difference was within ± 7.5%, and the results of microbial limit test were in accordance with Claim.