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目的评价纤维蛋白靶向结合MRI对比剂(EP-2104R)对兔颈动脉急性和亚急性血栓的显示能力,并与非对比增强和Gd-DTPA增强MRI对比。方法用颈动脉外部损伤和阻塞的方法在10只兔颈动脉内形成血栓,在血栓诱导后急性(6h)和亚急性(6d)组分别进行对比剂(EP-2104R)注入前及注入后MRI扫描,并作了组织病理学对比研究。结果纤维蛋白靶向对比剂准确的显示了所有血栓,优于非对比增强MRI和Gd-DTPA增强MRI(P<0.001)。GD-DTPA增强后不能提高发现血栓的能力。结论本研究发现纤维蛋白靶向对比剂在显示活体内急性和亚急性血栓方面优于非对比增强和Gd-DTPA增强MRI。
Objective To evaluate the ability of fibrin-targeted MRI contrast agent (EP-2104R) to display the acute and subacute thrombosis in rabbit carotid arteries and to compare with contrast-enhanced and Gd-DTPA-enhanced MRI. Methods Thromboembolism was induced in 10 rabbit carotid arteries by external carotid artery injury and occlusion. Before and after injection of contrast agent (EP-2104R), acute (6h) and sub-acute (6d) Scan, and made histopathological comparative study. Results The fibrin target contrast agent accurately showed all thrombi, superior to non-contrast enhanced MRI and Gd-DTPA enhanced MRI (P <0.001). GD-DTPA enhanced can not improve the ability to detect thrombus. Conclusions This study found that fibrin target contrast agents are superior to non-contrast enhancement and Gd-DTPA-enhanced MRI in showing acute and sub-acute thrombi in vivo.