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本文从1978年1月～1980年4月,对临床诊断为新生儿肝炎综合征的门诊及住院婴儿共78例,分别随机进行了血清AFP测定的动态观察,其中诊断为新生儿肝炎者62例(轻型30例,重型32例)。结果如下:(1)新生儿肝炎时,其血清AFP值升高占98.4%,轻型肝炎在31.5～50,000ng/ml,重型肝炎在320～100,000ng/ml;(2)血清AFP值的高低,主要与临床病情轻重有关,但与病程无明显相关,轻型肝炎83.33%在3,000ng/ml以下,重型肝炎90.63%在3,000ng/ml以上;(3)新生儿肝炎痊愈时,AFP值均降到正常,轻型肝炎78.5%呈直线下降,重型肝炎75%呈峰峦型下降,其恢复正常的时间较轻型肝炎为长;(4)讨论了有关问题和看法。
In this paper, from January 1978 to April 1980, a total of 78 outpatients and hospitalized infants clinically diagnosed as neonatal hepatitis syndrome were randomly divided into two groups: the dynamic observation of serum AFP was performed, of which 62 cases were diagnosed as neonatal hepatitis (Light 30 cases, heavy 32 cases). The results are as follows: (1) Neonatal hepatitis, the serum AFP value increased 98.4%, mild hepatitis in the 31.5 ~ 50,000ng / ml, severe hepatitis 320 ~ 100,000ng / ml; (2) serum AFP levels, Mainly associated with the severity of clinical conditions, but no significant correlation with the course of disease, 83.33% of mild hepatitis in less than 3,000ng / ml, severe hepatitis 90.63% in more than 3,000ng / ml; (3) Neonatal hepatitis AFP values were reduced to Normal, mild hepatitis 78.5% showed a straight line decline, 75% of severe hepatitis showed a decline in the mountain range, the longer time to return to normal than the mild hepatitis; (4) to discuss the issues and views.