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目的:分析抗感染药物不良反应(ADR)发生的特点和规律,促进临床合理用药。方法:对2009年度收集的310例抗感染药物ADR报告,按患者性别、年龄及诱发ADR的药物种类、给药途径、临床表现等进行分析。结果:310例抗感染药物ADR中,女50.65%(157/310),男49.35%(153/310);60岁以上患者发生ADR比率为35.81%(111/310);涉及14类59种药品,其中发生率最高为头孢菌素类29.35%(91/310),其次是喹诺酮类23.87%(74/310);静脉给药ADR82.58%(256/310);ADR临床表现中,皮肤及其附件损害最常见(38.84%)。结论:临床应合理使用抗感染药物,加强不良反应监测,减少ADR对患者的危害。
Objective: To analyze the characteristics and laws of adverse drug reaction (ADR) and to promote the rational use of clinical medicine. Methods: The ADR reports of 310 anti-infectives collected in 2009 were analyzed according to their gender, age, drug type, route of administration and clinical manifestations. Results: The ADR rates of 310 anti-infectives were 50.65% (157/310) and 49.35% (153/310) in men, respectively. The ADR rate was 35.81% (111/310) in patients over 60 years of age. , Of which the highest incidence of cephalosporins 29.35% (91/310), followed by quinolones 23.87% (74/310); intravenous administration of ADR82.58% (256/310); ADR clinical manifestations, skin and The attachment damage the most common (38.84%). Conclusion: The clinical should be rational use of anti-infective drugs, strengthen adverse reaction monitoring, reduce the risk of ADR in patients.