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目的:探讨雌激素受体相关受体(estrogen receptor related receptors,ERR)α、β、γ亚型表达与鼻咽癌的关系。方法:随机抽取健康体格合者40人为对照组,鼻咽癌患者40例为试验组,采用RT-PCR方法检测ERRs家族各亚型的mRNA表达,采用Westston Blot印迹方法检测ERR各亚型在鼻咽癌组织中的表达。结果:RT-PCR及Western Blot蛋白印记检测显示ERR-α在对照组低表达、在实验组高表达,两组患者外周血及鼻咽组织中ERR-β表达差异无统计学意义,ERR-γ在对照组高表达、在实验组低表达。结论:ERR-α和ERR-γ在鼻咽癌患者体内表达异常,其可能与鼻咽癌的发生发展相关。
Objective: To investigate the relationship between estrogen receptor related receptors (ERR) α, β and γ subtypes and nasopharyngeal carcinoma. Methods: 40 healthy subjects were randomly selected as the control group. Forty patients with nasopharyngeal carcinoma (NPC) were selected as the experimental group. The expression of mRNA of each subtypes of ERRs was detected by RT-PCR. West blot was used to detect ERR subtypes. Expression in pharyngeal cancer tissues. Results: The results of RT-PCR and Western Blot showed that the expression of ERR-α was low in the control group and high in the experimental group. There was no significant difference in the expression of ERR-β between the two groups High expression in the control group, low expression in the experimental group. Conclusion: The expression of ERR-α and ERR-γ in patients with nasopharyngeal carcinoma is abnormal, which may be related to the occurrence and development of nasopharyngeal carcinoma.