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研究了螺旋藻多糖 (PS)对环磷酰胺 (CY)引起的 BALB/C小鼠造血功能等损伤的保护作用。当给小鼠 CY时若能同时给予 (1 0 0 mg/kg) PS时 ,就能大大减轻因给予 CY引起的造血功能障碍 (P <0 .0 0 1 ) ;能明显减缓动物因使用CY所致的体重下降 (P <0 .0 2 )以及能明显减低因 CY作用的动物死亡率 (P <0 .0 5 )。提示使用 PS对预防或减轻化疗制剂的危害是具有明显作用的。为临床化疗、放疗病人使用 PS提供了依据。
The protective effect of polysaccharide from Spirulina platensis (PS) on hematopoietic impairment in BALB/C mice induced by cyclophosphamide (CY) was studied. When mice were given CY at the same time (100 mg/kg) PS, hematopoietic dysfunction caused by CY administration could be greatly reduced (P < 0.01); animals could be significantly slowed down by using CY. The resulting weight loss (P <0. 02) and the animal mortality due to CY were significantly reduced (P <0.05). It is suggested that the use of PS has a significant effect in preventing or reducing the harm of chemotherapy agents. It provides a basis for the use of PS in clinical chemotherapy and radiotherapy patients.