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目的探讨纳洛酮治疗急性胰腺炎的疗效。方法急性胰腺炎患者共44例,分为纳洛酮组与对照组,纳洛酮组每日静脉输注纳洛酮4mg加入5%葡萄糖溶液250ml中,其余常规治疗同对照组,观察血、尿淀粉酶及C反应蛋白(CRP)水平变化及临床症状纳络酮组改善程度。结果临床症状纳洛酮组较对照组恢复稍快,但无统计学差异;纳洛酮组治疗后第1、3、5、7天血淀粉酶水平明显低于对照组(P<0.05),尿淀粉酶水平于治疗后第1、5、7天及第2、3天较对照组明显降低(P<0.05,P<0.01),恢复到正常水平较对照组提前;纳洛酮组CRP水平在治疗前,治疗后3天开始有显著差别(P<0.01),对照组治疗前、后无明显差别(P>0.05)。结论静脉应用纳洛酮有助于急性胰腺炎的炎症恢复。
Objective To investigate the efficacy of naloxone in the treatment of acute pancreatitis. Methods A total of 44 patients with acute pancreatitis were divided into naloxone group and control group. Naloxone group was infused daily with naloxone 4mg into 250ml 5% dextrose solution. The other routine treatment was the same as control group. Blood, Changes in urinary amylase and C-reactive protein (CRP) levels and improvement in clinical symptoms of naloxone group. Results The symptoms of naloxone in the naloxone group recovered slightly faster than those in the control group, but no statistical difference was found. The levels of amylase in the naloxone group were significantly lower than those of the control group on the 1st, 3rd, 5th and 7th days after treatment (P <0.05) The level of urinary amylase in the naloxone group was significantly lower than that in the control group on the 1st, 5th, 7th and the 2nd and 3rd days after treatment (P <0.05, P <0.01) Before treatment, three days after treatment began to have significant difference (P <0.01), before and after treatment in the control group no significant difference (P> 0.05). Conclusion Intravenous naloxone is helpful for the recovery of inflammation in acute pancreatitis.