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目的:比较局部使用红霉素和派丽奥在预防非翻瓣种植术早期创口感染中的临床疗效。方法:选择40例非翻瓣种植术病例随机分配至派丽奥组实验A组17例、红霉素组实验B组18例和空白对照组C组5例,3组病例术后均口服抗生素3天。于种植术后3天,观察、分析3组间相关临床指标、龈沟液量和内毒素含量的变化。结果:临床观察指标中局部疼痛指数(PI)、龈沟出血指数(SBI)、种植体周软组织指数(PIST)3组间比较差异有统计学意义(P<0.05),对照组的临床指标与实验组差异均有统计学意义(P<0.05),而两实验组的临床指标差异无统计学意义(P>0.05).种植体周龈沟液量在B组(0.512±0.386)μL、A组(0.512±0.129)μL和C组(1.421±0.748)μL中差异存在统计学意义(P<0.05),C组的种植体周龈沟液量与A、B两组均有统计学差异(P<0.05),而A、B两组间无显著差异(P>0.05).内毒素在B组(7.057±10.019)EU/mL、A组(6.007±7.852)EU/mL和C组(20.351±17.130)EU/mL中存在统计学差异(P<0.05),C组的内毒素含量与A、B两组均有统计学差异(P<0.05),而A、B两组的内毒素含量无显著差异(P>0.05).PI、PIST与PICF之间没有显著的正相关关系(P>0.05),而SBI与PICF之间存在一定正相关关系(P=0.000)。内毒素同各项临床指标都有一定的正相关关系(P<0.05)。结论:术后局部用药联合全身用药可明显降低种植区软组织炎症反应;在种植术早期创口愈合中局部使用红霉素与派丽奥具有同样明显的效果,推荐使用性价比较高、使用方便、易于保存的红霉素软膏。
OBJECTIVE: To compare the clinical efficacy of topical erythromycin and palio in the prevention of wound infection in the early stage of non-flap surgery. Methods: Forty cases of non-flap surgery were randomly allocated to 17 cases in group A, 17 cases in group B of erythromycin group and 5 cases in group C of blank control group. All the 3 groups were given oral antibiotics 3 days. Three days after planting, the changes of relevant clinical indexes, gingival crevicular fluid volume and endotoxin content were observed and analyzed. Results: There were significant differences between the three groups in the clinical observation index of local pain index (PI), sulcus bleeding index (SBI) and implant peripheral soft tissue index (PIST) (P <0.05) (P <0.05), while there was no significant difference between the two experimental groups (P> 0.05) .The amount of gingival crevicular fluid in group B was (0.512 ± 0.386) μL, A There was significant difference between the group (0.512 ± 0.129 μL) and the group C (1.421 ± 0.748 μL) (P <0.05). There was a significant difference between group C and group A and B (P <0.05), but there was no significant difference between A and B groups (P> 0.05). The endotoxin levels were significantly higher in EU / mL group B (7.057 ± 10.019), EU group A (6.007 ± 7.852) ± 17.130) EU / mL (P <0.05). The endotoxin content in group C was significantly lower than that in group A and B (P <0.05), while the level of endotoxin in group A and B There was no significant positive correlation between PI, PIST and PICF (P> 0.05), but there was a positive correlation between SBI and PICF (P = 0.000). Endotoxin and the clinical indicators have a certain positive correlation (P <0.05). Conclusion: Local application of topical and systemic medication can significantly reduce the soft tissue inflammatory response in the planting area. The local use of erythromycin in the wound healing in the early stage of implantation has the same obvious effect as the Paragon. It is recommended to use the high cost, easy to use and easy to use Preserved erythromycin ointment.