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目的 观察左炔诺孕酮宫内系统 (LNG IUS)临床使用 5年的抗生育效果、副反应及探讨其使用的安全性。方法 对 10 0例经产妇 ,随机放置LNG IUS(LNG组 )和宫内节育器TCu380A(TCu组 )各 5 0例 ,定期随访。对 14例闭经者测定血清生殖激素水平及对 9例闭经者进行子宫内膜病理学检查。结果 TCu组 2例妊娠 ;LNG组无妊娠发生 ,因闭经停用 2 4例。 5年末续用率LNG组为2 4 0 % ,TCu组为 74 0 % (P <0 0 0 1)。 14例闭经者生殖激素水平与对照组相比 ,差别无显著性 (P >0 0 5 )。LNG组子宫内膜病理检查为内膜萎缩、少数腺体分泌现象。结论 LNG IUS导致的闭经是药物对子宫内膜的局限性抑制作用 ,是可逆的 ,对卵巢功能影响不大 ,卵巢仍能正常分泌激素。LNG IUS是一种可长期使用、低妊娠率、安全的避孕系统。
Objective To observe the anti-fertility effects and side effects of levonorgestrel intrauterine system (LNG IUS) for 5 years and to explore its safety. Methods A total of 100 maternal women with LNG IUS (LNG group) and TCu380A (TCu group) were randomly assigned to follow-up. 14 cases of menopause were measured serum levels of reproductive hormones and 9 cases of amenorrhea for endometrial pathology. Results TCu group 2 cases of pregnancy; LNG group no pregnancy, amenorrhea discontinuation of 24 cases. At the end of the 5-year follow-up, the LNG group was 240% and the TCu group was 74 0% (P 0 01). There was no significant difference in reproductive hormones between 14 menopause men and women in the control group (P> 0.05). LNG group of endometrial pathological examination for endometrial atrophy, a small number of glandular secretion. CONCLUSION: Amenorrhea caused by LNG IUS is a drug that has a limited inhibitory effect on the endometrium and is reversible with little effect on ovarian function. The ovaries still normally secrete hormones. LNG IUS is a long-term use, low pregnancy rate, safe contraceptive system.