张××,女,2月,陕西省礼泉县。患儿初生后即见鼻准部色泽较正常皮色为深,下腹部偏右侧可见一针尾大小之红色小疙瘩,半月后皮疹呈进行性增大,约为黄豆大,色呈淡红,境界为清,表面平滑,质地坚硬,指压时无不适反应,于25天时皮损呈杏核大,此时亦在左肩部、左腋部、背部同时出现类似皮损五处,均如针尖至绿豆大,且不断增大;于45天时,下腹部皮损已达核桃大小,背部皮疹增至鸽卵大小,平时按压时患儿无哭闹及躁动。曾赴西安某医院皮肤科就诊,取活检报告为“神经纤维瘤”。该婴诞生至今无罹其它任何疾患。精神、食欲及二便俱正常,追询亦无出血症象及高热、便血、消瘦史,其父患“十二指肠球部溃疡”达五年之久,对症诊处,现呈静止期;其母有“药疹”史,现愈。其祖父母、外祖父母俱健在。其母为一胎一产,足月顺产。查体:体温36.7℃,脉搏128次/分,呼吸32次/分。一般情况可,发育营养中等,无进行 Zhang × ×, female, February, Liquan County, Shaanxi Province. Children with nasal see after nasal color than the normal color is darker than the right side of the lower abdomen can be seen a pin tail size red small lumps, half a month after the rash was progressively increased, about soybeans, color was pink , The realm of clear, smooth surface, hard texture, acupressure no discomfort reaction, the skin lesions showed apricot on 25 days, this time also in the left shoulder, left axilla, back at the same time there are five similar lesions, both as The needle tip to the mung bean big, and increasing; at 45 days, the lower abdomen lesions have reached the size of the walnut, the back of the rash increased to the size of the pigeon eggs, usually no pressure when the child crying and restlessness. She went to a dermatology clinic in Xi’an and took biopsy report as “neurofibromas.” The infant has so far had no other illnesses since birth. Mental, appetite and two are all normal, there is no trace of hemorrhagic signs and fever, blood in the stool, weight loss history, his father suffering from “duodenal ulcer” for five years, the symptomatic clinic, the quiescent period ; Its mother has a history of "drug eruptions, and now more. His grandparents are strong. The mother of a fetus, full-term birth. Physical examination: body temperature 36.7 ℃, pulse 128 beats / min, breathing 32 beats / min. In general, developmental nutrition is moderate, no progress