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1临床资料患者男,72岁。口腔黏膜增生及手足皮肤增厚伴色素沉着8个月,累及全身2个月。8个月前患者出现进食时口腔疼痛,发现双侧口腔颊黏膜有黄豆大乳头状增生物,并逐渐增大和增多;同时手足掌跖角化过度,表面呈乳头瘤样增生,面部皮肤色泽加深,呈灰黑色,且皮纹加深,皮肤粗糙和增厚。曾于当地医院检查血、尿、粪常规、肝肾功、血糖及血脂未见异常;CEA31.27ng/mL(0～5ng/mL);胸部CT示右
1 Clinical data Patient male, 72 years old. Oral mucosal hyperplasia and hand, foot and skin hyperplasia with pigmentation for 8 months, involving the whole body for 2 months. 8 months ago, patients had oral pain when eating and found bilateral buccal mucosa soy papillary hyperplasia, and gradually increased and increased; at the same time hand-foot palm hyperkeratosis, the surface was papilloma-like hyperplasia, facial skin color deepened , Gray and black, and darker skin, skin roughness and thickening. Have a local hospital examination of blood, urine, fecal routine, liver and kidney function, blood glucose and blood lipids were no abnormalities; CEA31.27ng / mL (0 ~ 5ng / mL); chest CT showed right