目的对临床应用中左氧氟沙星发生不良反应进行研究和分析,为合理用药提供指导和参考。方法对我院使用左氧氟沙星治疗的1868例患者的临床资料进行回顾,总结临床常见左氧氟沙星的不良反应、损伤部位、预后及影响因素。结果发生不良反应243例(13.0%)以神经系统、消化系统及皮肤过敏等不良反应较为常见。结论左氧氟沙星发生不良反应在临床上较为常见,需引起临床医生的高度重视,并对不良反应采取及时有效地预防和处理,从而降低不良反应,提高临床用药的安全性。 Objective To study and analyze the adverse reactions of levofloxacin in clinical application so as to provide guidance and references for rational drug use. Methods The clinical data of 1868 patients treated with levofloxacin in our hospital were retrospectively reviewed. Adverse reactions, injury sites, prognosis and influencing factors of common levofloxacin were summarized. As a result, 243 patients (13.0%) had adverse reactions. The adverse reactions such as nervous system, digestive system and skin allergy were common. Conclusion Adverse reactions of levofloxacin are more common in clinical practice, which should be paid great attention to by clinicians. Adverse reactions should be taken timely and effectively to prevent and treat adverse reactions and improve the safety of clinical medication.