目的分析青岛地区妊娠早期孕妇乙肝、丙肝、艾滋病、梅毒和TORCH的感染情况,以指导临床加强对育龄夫妇的宣传教育工作,做好优生优育。方法收集2013年1月—2014年12月青岛市妇女儿童医院产科门诊收治的建卡妊娠早期孕妇的血清,采用ELISA方法检测血清标本中的HBV(HBs Ag,HBs Ab、HBe Ag、HBe Ab、HBc Ab)、HCV(HCV-c Ag、HCV-Ab)、HIV[HIV(1/2)-Ab]和TP(TP-Ab)血清标志物,采用电化学发光法检测TORCHIg M。采用SPSS 19.0统计软件进行分析,计数资料之间的比较采用χ~2检验,以P<0.05表示差异有统计学意义。结果青岛地区妊娠早期孕妇的HBs Ag阳性率为3.961%(650/16 411),HCV-Ab阳性率0.055%(9/16 411),HIV-Ab阳性率为0.000%(0/16 411),TP-Ab阳性率为0.585%(96/16 411),TORCH-Ig M总阳性率为9.194%(202/2 197)。高龄孕妇TP感染率为1.684%(26/1 544),显著高于适龄孕妇的0.471%(70/14 867,χ~2=33.34,P<0.01),同样高龄孕妇TORCH感染率为13.333%(30/225),显著高于适龄孕妇的8.722%(172/1 972,χ~2=4.61,P<0.05),而且HBs Ag、CMV-Ig M和HSV(1/2)-Ig M阳性率存在季节差异(HBs Ag:χ~2=10.52,P<0.05;CMV-Ig M:χ~2=14.11,P<0.01;HSV(1/2)-Ig M:χ~2=25.34,P<0.01)。结论青岛地区妊娠早期孕妇存在优生优育相关感染性病原体感染的现象,应加强对育龄夫妇的宣传教育,做好孕前和孕期乙肝、丙肝、艾滋病、梅毒和TORCH的筛查工作,提高优生优育。 Objective To analyze the prevalence of hepatitis B, hepatitis C, AIDS, syphilis and TORCH among pregnant women in early pregnancy in Qingdao in order to guide the clinical work of publicity and education on couples of childbearing age and to make good prenatal and postnatal care. Methods Serum samples from early pregnant women who were admitted to obstetrics and gynecology clinic of Qingdao Women’s and Children’s Hospital from January 2013 to December 2014 were collected. Serum HBV (HBs Ag, HBs Ab, HBe Ag, HBe Ab, HBc Ab, HCV (HCV-cAg, HCV-Ab), HIV [HIV (1/2) -Ab] and TP (TP-Ab) serum markers were detected by electrochemiluminescence TORCHIg M. Using SPSS 19.0 statistical software for analysis, the comparison between the count data using χ ~ 2 test to P <0.05 said the difference was statistically significant. Results The positive rate of HBsAg in pregnant women in early pregnancy in Qingdao was 3.961% (650/16 411), the positive rate of HCV-Ab was 0.055% (9/16 411), the positive rate of HIV-Ab was 0.000% (0/16 411) The positive rate of TP-Ab was 0.585% (96/16 411), and the total positive rate of TORCH-Ig M was 9.194% (202/2 197). The infection rate of TP in senior pregnant women was 1.684% (26/1 544), significantly higher than 0.471% (70/14 867, χ ~ 2 = 33.34, P <0.01) 30/225) was significantly higher than 8.722% (172/1 972, χ ~ 2 = 4.61, P <0.05) of pregnant women of the same age group, and the positive rates of HBs Ag, CMV-Ig M and HSV (1/2) There were seasonal differences (HBsAg: χ ~ 2 = 10.52, P <0.05; CMV-Ig M: χ ~ 2 = 14.11, P < 0.01). Conclusion Pregnant women in prenatal pregnancy in Qingdao have the infection of infectious pathogens associated with prenatal and postnatal care. The publicity and education of couples of childbearing age should be strengthened. Screening of hepatitis B, hepatitis C, AIDS, syphilis and TORCH before and during pregnancy should be done to improve prenatal and postnatal care.