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目的探讨不同部位注射~(99m)Tc标记的肌醇六磷酸盐联合亚甲蓝检测早期子宫内膜癌前哨淋巴结的价值。方法 50例子宫内膜癌患者分别在子宫浆膜层、宫颈和子宫浆膜层联合宫颈部位注射~(99m)Tc标记的肌醇六磷酸盐联合亚甲蓝,对术中和术后前哨淋巴结的检出率以及不同部位注射前哨淋巴结检出率及符合率分析。结果术中前哨淋巴结的术中检出率为78.6%,术后行病理检查发现,有20例患者存在转移灶,前哨淋巴结检测术的灵敏度为97.7%,特异度为42.9%,假阴性率为2.3%,阳性预测值为91.3%;三个不同注射部位的检出率和符合率比较差异均无统计学意义(P>0.05),且术前与术后前哨淋巴结阳性的检出率比较差异无统计学意义(P>0.05)。结论 ~(99m)Tc标记的肌醇六磷酸盐联合亚甲蓝检测对早期子宫内膜癌前哨淋巴结的诊断价值较高。
Objective To investigate the value of ~ (99m) Tc-labeled phytate combined with methylene blue in different sites for the detection of sentinel lymph node in early stage of endometrial cancer. Methods Fifty patients with endometrial carcinoma were injected with (99m) Tc labeled phytate combined with methylene blue respectively in the uterine serosa, cervix and uterine serosal junction and cervix. The intraoperative and postoperative sentinel lymph node The detection rate and the different parts of the sentinel lymph node detection rate and coincidence rate analysis. Results The intraoperative detection rate of sentinel lymph nodes was 78.6%. Postoperative pathological examination showed that there were 20 patients with metastases. The sensitivity and specificity of sentinel lymph node detection were 97.7% and 42.9%, respectively. The false negative rate was 2.3%, positive predictive value was 91.3%. There was no significant difference in the detection rate and coincidence rate among the three different injection sites (P> 0.05), and the positive rate of preoperative and postoperative sentinel lymph node positive was significantly different No statistical significance (P> 0.05). Conclusion ~ (99m) Tc-labeled phytate combined with methylene blue detection has a high diagnostic value for sentinel lymph node in early endometrial cancer.