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目的:分析住院患者质子泵抑制剂(PPI)不合理使用的原因,为合理用药提供参考。方法:抽取2016年11月普通外科、肛肠科、消化内科、心血管内科、神经外科住院患者使用PPI医嘱75份,分析其不合理使用的原因。结果:75份医嘱中不合理使用PPI 25份,合理的50份,其使用合理率为66.67%,其中有1份发生药品不良反应。结论:PPI临床合理使用率偏低,存在过度使用PPI以及未能全面考虑药物相互作用、禁忌证、适应证等因素,应加强或干预PPI的临床不合理使用,促进临床合理用药。
Objective: To analyze the reason of unreasonable use of proton pump inhibitor (PPI) in hospitalized patients and provide references for proper medication. Methods: Totally 75 inpatients with general inpatient, anorectal, gastroenterology, cardiology and neurosurgery were enrolled in November 2016. The reasons for their unreasonable use were analyzed. Results: The unreasonable use of 75 PPI PPI 25, a reasonable 50, the use of a reasonable rate of 66.67%, of which 1 occurred adverse drug reactions. Conclusion: The low rational use of PPI, the excessive use of PPI and the failure to fully consider the drug interactions, contraindications, indications and other factors should be strengthened or interfered with the clinical use of PPI unreasonable to promote clinical rational use of drugs.