A群链球菌性咽炎是学龄儿童最常见的细菌性感染。M蛋白是 A群链球菌的主要毒力决定簇和保护性抗原。每种 M蛋白的型特异性由位于氨基末端 40～ 50个氨基酸残基上的表位决定。因此 ,作者通过联合氨基末端M蛋白肽 ,构建了 2 6价 M蛋白疫苗 ,并用此疫苗进行免疫接种以确定其诱生保 Group A streptococcal pharyngitis is the most common bacterial infection in school-aged children. M protein is the major virulence determinant and protective antigen of Group A Streptococcus. The type specificity of each M protein is determined by the epitope located on the 40 to 50 amino acid residues at the amino terminus. Thus, the authors constructed a 26-valent M protein vaccine by combining the amino-terminal M-protein peptide and immunized with this vaccine to determine its induction