新生儿持续肺动脉高压(PPHN)是由于生后胎儿型循环过渡到成人型循环发生障碍所导致的危重急症,病死率高,治疗棘手,是临床亟待解决的课题。近年来,国内外关于PPHN治疗的研究取得一定的突破,包括一氧化氮吸入疗法、磷酸二酯酶抑制剂、依前列醇及其类似物、内皮素受体拮抗剂及抗氧化剂的应用,现将新近的治疗进展进行综述。 Continuous neonatal pulmonary hypertension (PPHN) is due to postnatal fetal cycle transition to adult circulatory disorders caused by critical illness, high mortality, the treatment of intractable, is a clinical problem to be solved. In recent years, domestic and foreign research on PPHN made some breakthroughs, including nitric oxide inhalation therapy, phosphodiesterase inhibitors, epoprostenol and its analogues, endothelin receptor antagonists and antioxidants, the application of A review of recent treatment progress will be made.