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目的通过分析新疆维吾尔族、哈萨克族正常糖耐量人群和2型糖尿病患者血浆中脂多糖结合蛋白(LBP)、可溶性白细胞分化抗原14(sCD14)及LBP/sCD14水平的变化,探讨LBP、sCD14、LBP/sCD14与新疆维吾尔族、哈萨克族2型糖尿病(T2DM)的相关性。方法采用酶联免疫吸附法(Elisa)检测LBP、sCD14在血浆中的浓度。两组间均数比较采用t检验,运用Pearson分析方法对血浆LBP、sCD14、LBP/sCD14与新疆维吾尔族、哈萨克族2型糖尿病和糖耐量正常人群的空腹血糖(FBG)、年龄、身高、体重、体重指数(BMI)、腰围、胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)做相关性分析。结果与哈萨克族糖耐量正常组相比较,该民族T2DM组中LBP和LBP/sCD14的表达量升高且差异均有统计学意义(P=0.012,P=0.003);与哈萨克族糖耐量正常组相比,维吾尔族糖耐量正常组血浆LBP和LBP/sCD14的表达量升高且差异均有统计学意义(P=0.005,P=0.006)。血浆LBP的含量与相对应的FBG、体重、BMI、TC、TG、HDL-C存在一定的相关性及LBP/sCD14与FBG、TG显著正相关性。结论与哈萨克族糖耐量正常组相比较,LBP和LBP/sCD14的表达量在哈萨克族2型糖尿病组和维吾尔族糖耐量正常组均显著升高。
OBJECTIVE: To investigate the changes of plasma lipopolysaccharide binding protein (LBP), soluble leukocyte differentiation antigen 14 (sCD14) and LBP / sCD14 levels in Xinjiang Uygur and Kazak normal glucose tolerance and type 2 diabetes mellitus / sCD14 and Xinjiang Uigur and Kazak type 2 diabetes mellitus (T2DM). Methods The concentrations of LBP and sCD14 in plasma were detected by Elisa. The mean of the two groups was compared by t-test, and the fasting blood glucose (FBG), age, height, body weight of LBP, sCD14, LBP / sCD14 and normal Uygur and Kazak people with type 2 diabetes and normal glucose tolerance in Xinjiang were analyzed by Pearson analysis. , Body mass index (BMI), waist circumference, cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) Results Compared with Kazakh normal glucose tolerance group, the expression levels of LBP and LBP / sCD14 in T2DM group were significantly increased (P = 0.012, P = 0.003). Compared with Kazakh normal glucose tolerance group Compared with Uighur group, the levels of plasma LBP and LBP / sCD14 in normal glucose tolerance group were significantly increased (P = 0.005, P = 0.006). There was a certain correlation between plasma LBP level and FBG, body weight, BMI, TC, TG, HDL-C and LBP / sCD14 with FBG, TG. Conclusion The expression levels of LBP and LBP / sCD14 are significantly higher in Kazak type 2 diabetes mellitus and Uighur group with normal glucose tolerance than those in normal Kazakh.