观察西咪替丁和雷尼替丁对大鼠小肠纵行肌条自发收缩活动的影响 .结果表明 :1西咪替丁 4mmol· L-1降低回肠肌条的收缩波平均振幅 ,雷尼替丁 2 mmol· L-1增大回肠肌条的收缩波平均振幅 . 2西咪替丁 1 - 4mmol· L-1,雷尼替丁 5mmol·L-1对十二指肠 ,头端空肠 ,末端空肠肌条的收缩活动呈抑制作用 ,雷尼替丁 2 mmol· L-1呈兴奋作用 .结果提示 :1西咪替丁抑制大鼠回肠肌条 ,而雷尼替丁兴奋大鼠回肠肌条 . 2西咪替丁和雷尼替丁对十二指肠 ,头端空肠及末端空肠肌条的抑制作用并非经由 H2 受体介导 The effects of cimetidine and ranitidine on spontaneous contraction of rat intestine longitudinal strips were observed.The results showed that: 1 Cimetidine 4 mmol · L-1 reduced the average amplitude of contraction wave of ileum strips, Ding 2 mmol · L-1 increased the average amplitude of contraction wave of ileum strips.2 The effect of 5 mg · L-1 cimetidine and ranitidine 5 mmol·L-1 on the duodenum, The contractile activity of terminal jejunal myoblasts was inhibited, and ranitidine 2 mmol · L-1 was excited.The results suggest that: 1 cimetidine inhibit rat myenteric myoblasts, and ranitidine excited rat ileum Article 2 The inhibitory effects of cimetidine and ranitidine on duodenum, head jejunum and terminal jejunal myoblasts were not mediated by H2 receptor