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目的观察磷酸西格列汀联合二甲双胍治疗2型糖尿病的临床疗效。方法选取2型糖尿病患者80例,随机分为观察组和对照组各40例,对照组采用磷酸西格列汀治疗,观察组采用磷酸西格列汀联合二甲双胍治疗。治疗1个月后,比较2组患者临床治疗效果、空腹血糖、餐后2 h血糖、体质量指数、糖化血红蛋白指数及胰岛素含量等。结果观察组总有效率为95.0%,高于对照组的75.0%,差异有统计学意义(χ~2=6.27,P<0.05);体质量指数、胰岛素情况均优于对照组,差异有统计学意义(P<0.05);空腹血糖、餐后2h血糖、糖化血红蛋白水平均低于对照组,差异有统计学意义(P<0.05)。结论磷酸西格列汀联合二甲双胍治疗2型糖尿病临床疗效显著,值得推广应用。
Objective To observe the clinical efficacy of sitagliptin phosphate and metformin in the treatment of type 2 diabetes mellitus. Methods Eighty patients with type 2 diabetes mellitus were randomly divided into observation group (40 cases) and control group (40 cases). The control group was treated with sitagliptin phosphate. The observation group was treated with sitagliptin phosphate and metformin. One month after treatment, the clinical effects, fasting blood glucose, postprandial blood glucose, body mass index, glycosylated hemoglobin index and insulin content were compared between the two groups. Results The total effective rate in the observation group was 95.0%, which was higher than that in the control group (75.0%), the difference was statistically significant (χ ~ 2 = 6.27, P <0.05); body mass index and insulin were better than the control group (P <0.05). The levels of fasting blood glucose, postprandial 2h blood glucose and glycosylated hemoglobin were all lower than those of the control group (P <0.05). Conclusion Sitagliptin phosphate combined with metformin has a significant therapeutic effect on type 2 diabetes mellitus, which is worth popularizing.