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目的:头颈部肿瘤放疗过程中的一个重要毒性反应是口腔黏膜炎症引起的疼痛。本研究是随机、双盲、安慰剂对照的试验,旨在验证盐酸多塞平减轻放射性口腔黏膜炎引起的疼痛效果。对象与方法:155例放射性口腔黏膜炎引起疼痛的患者随机分为多塞平治疗组和安慰剂组。第1天患
OBJECTIVE: One of the major toxicities in the radiotherapy of head and neck cancer is the pain associated with oral mucosal inflammation. This study was a randomized, double-blind, placebo-controlled trial designed to validate the effect of doxepin in reducing pain caused by radiation-induced oral mucositis. Subjects and Methods: A total of 155 patients with radiation-induced oral mucositis pain were randomly assigned to receive doxepin and placebo. The first day of suffering