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目的 探讨复发转移乳腺癌的临床病理特点 ,最佳治疗方法和治疗效果。方法 对3 4例复发转移乳腺癌病人 ,采取化疗 ,结合手术 ,放射治疗 ,术后继续化疗。结果 2 3例伴有内脏转移的 2个部位以上复发转移病人 ,经化疗病灶缩小明显 (PR) 7例 ,病情稳定 (SD ) 8例 ,病情进展(PD) 8例 ,临床获益 (CR +PR +SD) 65 % (15 / 2 3 )。 1年生存率 65 % ,11例局部复发化疗后病灶缩小 (PR) 10例 ,病情进展 (PD) 1例 ,临床获益 90 % (10 / 11) ,2年无瘤生存率 90 %。结论 伴有内脏转移的复发转移应以化疗为主 ,病灶缩小者 ,局部手术切除 ,放疗 ,术后继续化疗。显著延长生存时间。局部复发无内脏转移 ,也应先化疗 ,再手术 ,可减少远隔器官转移。
Objective To investigate the clinicopathological features, the best treatment and the therapeutic effect of recurrent breast cancer. Methods Thirty-four patients with recurrent breast cancer were treated with chemotherapy, combined with surgery and radiotherapy, followed by chemotherapy. Results Twenty - three patients with recurrence and metastasis from two sites with visceral metastases had 7 patients with clinically significant reduction (PR), 8 patients with stable disease (SD), 8 patients with progression (PD), 8 patients with clinical benefit (CR + PR + SD) 65% (15/2 3). The 1-year survival rate was 65%. In 11 cases, 10 cases were found with lesion lesion (PR), 1 case with disease progression (PD), 90% (10/11) clinical benefit, and 2 years disease-free survival rate 90%. Conclusion The recurrence and metastasis with visceral metastasis should be based on chemotherapy, lesion reduction, local surgical excision, radiotherapy, postoperative chemotherapy. Significantly prolongs survival time. Local recurrence without visceral metastasis, chemotherapy should be the first, then surgery, can reduce distant organ metastasis.