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系统性红斑狼疮 (ＳＬＥ)是一种多器官受累的自身免疫性疾病 ,病因复杂。Ｔ细胞受体 (ＴＣＲ) ζ链是一种关键的信号转导分子 ,它在大多数ＳＬＥ患者Ｔ细胞中的表达水平显著降低。但ＳＬＥＴ细胞中ＴＣＲ/ＣＤ3触发下游信号转导中间体磷酸化和游离钙离子浓度的增加 ,说明存在另
Systemic lupus erythematosus (SLE) is a multiple organ-involved autoimmune disease with a complex cause. T cell receptor (TCR) ζ chain is a key signal transduction molecule that is significantly reduced in T cells in most SLE patients. However, TCR / CD3 triggers downstream signal transduction intermediate phosphorylation and increased calcium ion concentration in SLET cells, indicating the existence of another