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目的观察吉西他滨、奥沙利铂、强的松联合化疗在外周T细胞淋巴瘤治疗中的近期疗效。方法对6例经多周期CHOP方案联合化疗无效的外周T细胞淋巴瘤患者更换化疗方案,具体为吉西他滨1000mg/m2+生理盐水100ml,静脉滴注30min,第1、d8天;奥沙利铂100mg/m2+5%葡萄糖注射液250ml静脉滴注3～4h,第1天;强的松60mg/m2,口服,第1～5天。结果 6例患者中完全缓解(CR)1例,部分缓解(PR)3例,稳定(SD)1例,进展(PD)1例总有效率66.7%。未发生治疗相关性死亡。结论对于复发性外周T细胞淋巴瘤患者或初诊为外周T细胞淋巴瘤患者,吉西他滨、奥沙利铂、强的松联合化疗不失为一个安全可行的方法。
Objective To observe the short-term effect of gemcitabine, oxaliplatin and prednisone combined with chemotherapy in the treatment of peripheral T-cell lymphoma. Methods Six patients with peripheral T-cell lymphoma who were treated with multi-cycle CHOP regimen and chemotherapy were discontinued. The regimen was replaced by gemcitabine 1000mg / m2 + saline 100ml, intravenous infusion 30min, day 1 and d8, oxaliplatin 100mg / m2 + 5% glucose injection 250ml intravenous infusion of 3 ~ 4h, the first day; prednisone 60mg / m2, orally, the first 5 days. Results Among the 6 patients, there were 1 complete remission (CR), 3 partial remission (PR), 1 stable (SD) and 1 (66.7%) progressive (PD). No treatment-related deaths occurred. Conclusions Gemcitabine, oxaliplatin and prednisone combined with chemotherapy are a safe and feasible method for patients with recurrent peripheral T-cell lymphoma or newly diagnosed peripheral T-cell lymphoma.